Last updated: 2021-11-23

Checks: 2 0

Knit directory: paed-BAL-meth-ref/

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Rmd 5169214 Jovana Maksimovic 2021-11-23 wflow_publish(c(“analysis/index.Rmd”, “analysis/estimateCellProportions.Rmd”))
html 8400f0f Jovana Maksimovic 2021-09-28 Build site.
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Rmd ba5a59c Jovana Maksimovic 2021-09-27 Start workflowr project.

Methylation profiling of purified cell types from paediatric Bronchoalveolar Lavage (BAL)

This site contains the results of the analyses performed to develop a genome-wide DNA methylation reference panel of the clinically-relevant constituent cell types of paediatric BAL collected from children with cystic fibrosis. This reference panel can be used in conjunction with appropriate reference-based deconvolution methods to adjust for cell composition in epigenome-wide association studies of pulmonary health and disease, particularly in paediatric cohorts.

Follow the links below to view the different parts of the analysis.

Analysis

  • Data cleaning, processing and processing
    • Data pre-processing: Quality control, normalisation and exploration of the BAL methylation data.
  • Estimating cell type proportions
    • Estimate proportions: Estimation of cell type proportions in the paediatric samples using the custom BAL methylation reference panel.

Licenses

The code in this analysis is covered by the MIT license and the written content on this website is covered by a Creative Commons CC-BY license.